Baltej Singh Lailna, 31, is accused of murdering his wife, Kamaljeet Sidhu, in their Quakers Hill house in western Sydney on Wednesday evening. The 27-year-old victim was found with a knife wound and died at the scene.
Lailna was arrested and taken to Blacktown Hospital for treatment to lacerations on his hands before being charged on Thursday.
Wrapped in a blanket, he appeared on Friday via video link in Parramatta Local Court, where he did not apply for bail and it was formally refused.
Lailna is next due to face Penrith Local Court on July 17.
Detectives say the couple had spoken to officers on April 24 at Quakers Hill Police Station, where Ms Sidhu made a complaint.
She was fearing for her life and an apprehended domestic violence order was issued against her husband, police have said.
If you have experienced sexual assault, domestic or family violence, call 1800 RESPECT on 1800 737 732.