It’s believed at least three people are dead after a semi-trailer and multiple cars crashed on the Chandler Highway near Kew about 5.40pm.
Officers had pulled a car over for a roadside test.
“Emergency services are currently responding to a collision in Kew tonight,” Victoria Police said in a statement.
“At this stage it is believed multiple vehicles are involved in the collision on the Chandler Highway and a number of police officers are believed to have been involved.
“The exact circumstances surrounding the incident are yet to be determined at this stage. We will provide updates as they come to hand.”
Multiple ambulances were seen leaving the scene.
Citybound lanes of the Eastern Freeway are closed between Bulleen Road and the Chandler Highway.
Motorists are being urged to exit the citybound lanes as early as possible and to find an alternative route.
Drivers can get back onto the freeway from the Chandler Highway entry.
Outbound traffic is heavily delayed through the area, so motorists should allow extra time.