Only players and officials from both teams were in attendance at Brisbane’s Hickey Park, with supporters not permitted to attend AFLW matches due to the coronavirus pandemic.
Despite the lack of a crowd, it was a bruising first quarter played at a frantic pace.
Layton fractured her finger in the opening minutes and did not take to the field again, while Brisbane winger Sophie Conway also came off early following a crunching tackle, but was able to return.
Despite the loss of Layton in the ruck, Collingwood capitalised on their domination of possessions and weight of forward-50 entries with goals to Sarah Rowe and Sophie Alexander helping them to a 15-point quarter-time lead.
Collingwood continued their stranglehold in defence in the second period, holding the Lions goalless to half-time while jumping out to a 24-point lead thanks to a Chloe Molloy set-shot goal.
The visitors were nearly made to pay for their wastefulness in front of goal in the third quarter, with the Lions scoring the only two majors for the term.
Catherine Svarc gave the Lions hope when she kicked Brisbane’s first with a nice running goal from about 25 metres out, while a late Dakota Davidson effort cut the deficit to just 14 points at the final break.
But it wasn’t enough to save the match, with D’Arcy making up for her earlier inaccuracy to kick the sealing goal for the Magpies in the last quarter.
Rheanne Lugg, Emily Bates and Kate Lutkins were among Brisbane’s best.