It could make the Friday trip home a nightmare for many.
Queensland Ambulance were called to Herschel Street in North Quay at 1.56pm following reports of a two vehicle incident.
One patient was taken to hospital in a stable condition.
The crash has partly blocked traffic and is causing major delays in the area.
— RACQ (@RACQOfficial) February 14, 2020
Traffic is backed up long the Riverside Expressway and Coronation Drive.
Police are on the scene and motorists are being warned to avoid the area if possible.
There was also an earlier truck crash on the Cunningham Highway, resulting in the road being blocked northbound.
It is unclear when it will be reopening.