Police were called to the scene just before 10am following reports of a crash 60 kilometres west of Jabiru on the Arnhem Highway.
Jabiru Police attended the scene where the vehicle had left the road, rolled and crashed into nearby trees.
“Tragically, five persons were found deceased upon arrival,” Northern Territory Police said in a statement.
“Investigators are currently working to establish the identities of the deceased, so that families can be notified.”
The Arnhem Highway remains closed to all traffic while police work to identify and recover the deceased.
More to come.