The Cowboys have the required cap space to pay Mitchell close to his $1 million-per-season asking price.
If they do successfully lure him north, they will be forced to offload several players if they are to also accommodate Holmes.
Coach Paul Green would also be presented with a selection headache, as both Mitchell and Holmes believe their best position is fullback.
That is part of the reason Mitchell has spent the summer looking for a new football home, according to his current coach, Trent Robinson.
“I think he wants to play fullback,” Robinson said on Melbourne radio station SEN.
“I think that’s his desire, so he’s going to go and explore the opportunities. It’s as simple as that. There’s no angst there.
“It’s just … he’s out there looking at the moment.”
Robinson said there were no hard feelings at Roosters HQ towards Mitchell, who has all but certainly played his final game in red, white and blue.
“There’s a lot been said but Latrell’s a good man and he’s delivered for the Roosters, and he wants to explore his opportunities,” Robinson said.
“A lot’s been written and we’re happy for him to do that.
“It’s just, we can’t sit and wait for that to happen. We’ve got to move on as well.”
While the Cowboys make their play for Mitchell, the Tigers are still hoping they can lure the star Kangaroos centre to Concord.
Coach Michael Maguire, CEO Justin Pascoe and head of football Adam Hartigan all travelled north to Taree during the week to meet with the 22-year-old.
A four-year deal worth just shy of $4 million is now being prepared to put in front of Mitchell, who will earn north of his $1 million per season asking price in 2022 and 2023 should he sign on the dotted line.
New Tigers chairman Lee Hagipantelis made another public push for the star centre on Monday.
“We want Latrell at the Tigers next year, there’s no doubt about it,” Hagipantelis said on Big Sports Breakfast. “He’s a quality human being and a quality player on and off the field.
“The lines of communication with Latrell and his management have been opened. We would not be the only club that would be interested in a marquee player of Latrell’s stature in the game.
“He would be a huge acquisition and an endorsement of what this club is doing and where it’s going.”
Hagipantelis said the acquisition of Mitchell would help reinstate the Tigers as one of the NRL’s glamour clubs.
“I might be somewhat biased but I regard us as a glamour club,” he said.
“We are transitioning, there’s no doubt about it. The acquisition of Michael Maguire elevates us to a whole new level. The board is now stable.
“A lot of the issues with respect to the salary cap in previous years have been largely resolved.
“The club is ready to leap-frog and move into a whole new dimension as far as success is concerned.”
Sam is a sports reporter for The Sydney Morning Herald.